Synthesis & Isolation

ChromaDex has acquired a wide range of experience and expertise in the natural products area. Our base in isolation of reference standards, reference material development, and analytical testing has led to the formation of a world class team of Natural Product Chemists, Analytical Chemists and Pharmacognosists. ChromaDex Contract Research Services can help customers solve a wide variety of challenges, from sourcing appropriate raw materials and identification of new compounds to process development for large scale manufacture. This Contract Research Service is ideal for any sized organization that wants to leverage the experience of our expert team to solve problems or to aid in the development of new products.

Examples of contract research services offered by ChromaDex:

• Target compound isolation
• Botanical sourcing & compound identification via MS or NMR
• Synthetic chemistry
• Process development

Target Compound Isolation

Isolating or extracting a specific chemical compound or family of compounds is a service that ChromaDex has a wealth of experience in performing. Whether you have your own process or if you want ChromaDex to develop the process for you, ChromaDex can handle all of your milligram to kilogram compound needs.

For example:

• Isolate a key compound from biomass or a complex matrix
• Identify side stream compounds of interest during the isolation process
• Separate a specific compound from an intermediate or extract product
• Create a library of compounds from an extraction process for use in high throughput screening

Examples of types of compounds we have isolated:

• Saponins, triterpenes, triterpene glycosides
• Flavonoids and flavonoid glycosides
• Carotenoids
• Quassinoids and alkaloids
• Fatty acids
• Phenolic acids
• Tannins
• Quinones and anthraquinones
• Phytosterols and steroid related structures
• Limonoids
• Many others….

Synthetic Chemistry

Synthesizing a specific compound can be a more cost effective means of obtaining a consistent material at the required quantities and purity.

ChromaDex is uniquely positioned to provide services such as:

• Perform feasibility studies
• Identify economical synthetic routes to produce a targeted product
• Synthesize the desired final product using low cost intermediate or starting materials
• Take an existing synthetic route and reduce the total number of required steps
• Improve yield from a client’s synthetic process

Process Development

Once you have selected your biomass and completed your research, it is time to scale up. ChromaDex works in all phases of project development, from process concept to fullscale production. This includes process research and innovation, scale-up, design, construction, operation of pilot plant or laboratory units, technology transfer, and optimization of manufacturing processes. Our process development team also taps into ChromaDex industry experts as well as outside technical resources like universities, government and private research organizations, and equipment vendors. The real value for clients is in increased rate of innovation and reduced timeto-market for new products and processes. By working closely with the scientific, engineering, and business staff of its clients, ChromaDex builds a seamless project team, acting as an extension of the client’s own R&D capabilities.

Process Development:

• Analytical development (pre-process)
• Process research (milligrams and grams)
• Process development
• Process scale-up (grams to kilograms)
• Capital and operating cost evaluation
• Cost-benefit analysis
• Project management and process engineering
• Detail design
• Process transfer

ChromaDex has performed process development projects for:

• Dietary supplement ingredients: extraction and purification
• Cosmetic ingredients: extraction and purification
• Pharmaceutical ingredient R&D: extraction
• Purification and synthesis

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